New cytokinin derivatives for agriculture and medicine

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F04%3A00002278" target="_blank" >RIV/61989592:15310/04:00002278 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
New cytokinin derivatives for agriculture and medicine
Original language description
New series of cytokinins derived from 6-benzylaminopurine have been developed for agricultural and biotechnological applications. These compounds exhibit very high biological activities in different cytokinin bioassays. The methoxy and fluoro derivativesexhibited 2-10 times higher activity then trans-zeatin and expressed very positive antisenescent and morphogenetic properties in different in vitro cultures. Among aromatic cytokinin derivatives, we have discovered a compound, 2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine, named "olomoucine" (OC), which specifically inhibits some cyclin-dependent kinases (CDKs) at micromolar concentration. The design and inhibitory activity of OC was further improved by modifications at positions 2, 6, and 9. This has led to development of specific CDK inhibitors like roscovitine, olomoucine II and purvalanol A, which display an enhanced inhibitory activity toward CDK1, a higher selectivity for some CDKs, an increased antimitotic activity at the
Czech name
Nové deriváty cytokininů pro zemědělství a medicínu
Czech description
Jsou popsány nové deriváty cytokininů pro zemědělství a medicínu.

Project
<a href="/en/project/GA522%2F01%2F0275" target="_blank" >GA522/01/0275: Study of new cytokinin metabolites: isolation, identification and biosynthesis</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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