CD4(+)-T-cell responses generated during murine Salmonella enterica serovar typhimurium infection are directed towards multiple epitopes within the natural antigen FliC

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F05%3A00010746" target="_blank" >RIV/61989592:15310/05:00010746 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

CD4(+)-T-cell responses generated during murine Salmonella enterica serovar typhimurium infection are directed towards multiple epitopes within the natural antigen FliC

Original language description

The flagellar filament protein FliC is a natural antigen recognized by memory CD4+-T cells recovered from Salmonella enterica serovar Typhimurium-infected humans and mice. To further investigate T-cell response to FliC, we derived FliC-specific CD4+-T-cell clones from mice of two different haplotypes following oral S. enterica serovar Typhimurium infection. Using C-terminal truncations of MalE-FliC recombinant vision proteins, we mapped antigenic activity to four different regions of FliC; three of thefour epitope-containing regions were present in both FliC and the alternate flagellin subunit FljB. We determined that two novel FliC epitopes were also present in flagellins from several gram-negative enteric bacterial species: Ek-restricted FliC 80?94(amino acids 80 to 94) and Ab-restricted FliC 455?469. Further mapping confirmed the presence of two previously identified FliC epitopes: Ak-restricted FliC 339?350 and Ab-restricted FliC 428?442. Therefore, like the recognition site of t

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EG - Zoology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2005

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Infection and Immunity

ISSN

0019-9567

e-ISSN

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Volume of the periodical

73

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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