Synthesis and cytotoxic activity of substituted 2-phenyl-3-hydroxy-4(1H)-quinolinones-7-carboxylic acids and their phenacyl esters

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F06%3A00003258" target="_blank" >RIV/61989592:15310/06:00003258 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/06:00083355 RIV/61989592:15310/06:00002755
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Synthesis and cytotoxic activity of substituted 2-phenyl-3-hydroxy-4(1H)-quinolinones-7-carboxylic acids and their phenacyl esters
Original language description
The preparation of 3-hydroxy-2-phenyl-4(1H)-quinolinones substituted in position 7 with a carboxyl group is described. The synthesis is based on the reaction of 2-aminoterephthalic acid with substituted α-bromoacetophenones and subsequent cyclization of the resulting bisphenacylesters in polyphosphoric acid. The reaction affords a mixture of substituted 3-hydroxy-2-phenyl-4(1H)-quinolinones 7-carboxylic acids as well as their phenacylesters. All quinolinones prepared (acids and phenacylesters) weretested for cytotoxic activity in vitro against five cancer cell lines and the results and a tentative structure-activity relationship are reported
Czech name
Syntéza a cytotoxická aktivita substituovaných 2-fenyl-3-hydroxy-4(1H)-chinolinon 7-karboxylových kyselin a jejich fenacylesterů.
Czech description
V článku je řešena syntéza derivátů 2-fenyl-3-hydroxy-4(1H)-chinolinon 7-karboxylových kyselin a vliv jejich struktury na cytotoxickou aktivitu na vybraných nádorových liniích.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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