Preparation, biological activity and endogenous occurrence of N6-benzyladenosines

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F07%3A00004610" target="_blank" >RIV/61989592:15310/07:00004610 - isvavai.cz</a>

Alternative codes found

RIV/61389030:_____/07:00305966

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Preparation, biological activity and endogenous occurrence of N6-benzyladenosines

Original language description

Cytokinin activity of forty-eight 6-benzyladenosine derivatives at both the receptor and cellular levels as well as their anticancer properties were compared in various in vitro assays. The compounds were prepared by the condensation of 6-chloropurine riboside with corresponding substituted benzylamines and characterized by standard collection of physico-chemical methods. The majority of synthesized derivatives exhibited high activity in all three of the cytokinin bioassays used (tobacco callus, wheat leaf senescence and Amaranthus bioassay). The highest activities were observed in the senescence bioassay. For several of the compounds tested, significant differences in activity were found between the bioassays used, indicating that diverse recognitionsystems may operate. This suggests that it may be possible to modulate particular cytokinin-dependent processes with specific compounds. In contrast to their high activity in bioassays, the tested compounds were recognized with only very

Czech name

Příprava, biologická aktivita a endogenní výskyt N6-benzyladenosinů

Czech description

Měřili jsme cytokininovou aktivitu čtyřiceti šeti 6-benzyladenosinových derivátů v receptorových a buněčných testech a také v několika in vitro testech. Článek popisuje syntézu studovaných látek, a jejich charakterizaci fyzikálně-chemickými metodami. Většina připravených látek vykazovala vysskou aktivitu ve vsšch cytokininových biotestech. Některé z nich byly studovány také v receptorových testech s rekombinantními receptory Arabidopsis thaliana AHK3 a AHK4.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioorganic & Medicinal Chemistry

ISSN

0968-0896

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

3737-3747

UT code for WoS article

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EID of the result in the Scopus database

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