New analogues of a potent cytotoxic saponin OSW-1

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F07%3A00004673" target="_blank" >RIV/61989592:15310/07:00004673 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/07:00308795
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
New analogues of a potent cytotoxic saponin OSW-1
Original language description
Saponin OSW-1 (5e-G2) analogues: with modified side chain (5a/d-G2), 22-deoxo-23,24,25,26,27-pentanor- (14), 22-deoxo-23-oxa- (17), glycosylated with various monosaccharides (5e-G4/G6/G8), and OSW-1 structural isomer (10) were obtained. The synthesis ofanalogues based on the method elaborated previously by us for the synthesis of OSW-1. The structures of all compounds were fully confirmed by spectroscopic methods; the S-chirality on the carbon atom C-22 of 10 was established by conformational analysiscombined with the NMR data analysis. The cytotoxic activity of the analogues against several malignant tumor cells was examined and compared with that of OSW-1. The results suggest that modification of steroidal aglycone may lead to compounds of high cytotoxicity.
Czech name
Nové analogy cytotoxického OSW-1
Czech description
Byli připraveny nalalogy saponiny OSW-1. Byla srovnávána cytotoxická aktivita těchto analog ze saponinem OSW-1, výsledky ukazují, že tyto nové analogy jsou potenciálně učinnější než OSW-1.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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