Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F11%3A33118173" target="_blank" >RIV/61989592:15310/11:33118173 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/11:00368598
Result on the web
<a href="http://dx.doi.org/10.1021/jm101648h" target="_blank" >http://dx.doi.org/10.1021/jm101648h</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/jm101648h" target="_blank" >10.1021/jm101648h</a>

Result language
angličtina
Original language name
Synthesis and Biological Activity of 22-Deoxo-23-oxa Analogues of Saponin OSW-1
Original language description
Analogues of the potent cytotoxic saponin OSW-1 were prepared from the readily available steroidal 16 beta,17 alpha,22-triol. The new 22-deoxo-23-oxa analogues of OSW-1 were screened against eight cancer cell lines and normal human fibroblasts. The analogues proved to be slightly less active than OSW-1 but also less toxic to normal cells. They induce concentration- and time-dependent apoptosis of mammalian cancer cells with caspase-3 activation
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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