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The first platinum(IV) complexes involving aromatic cytokinins or cyclic-dependent kinase inhibitors derived from 6-benzylaminopurine: X-ray structures of (BohH(2)(2+))[PtCl6].H2O and (RosH(2)(2+)(2)[PtCl6]Cl2.4H2O

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F07%3A00004798" target="_blank" >RIV/61989592:15310/07:00004798 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    The first platinum(IV) complexes involving aromatic cytokinins or cyclic-dependent kinase inhibitors derived from 6-benzylaminopurine: X-ray structures of (BohH(2)(2+))[PtCl6].H2O and (RosH(2)(2+)(2)[PtCl6]Cl2.4H2O

  • Original language description

    A series of Pt(IV) complexes with cytokinins or CDK-inhibitors derived from 6-benzylaminopurine (Bap) of the composition [Pt-IV(LH+)Cl-5] (1-14), where LH+ stands for protonated form of the bap derivate (1-12), Boh = 6-(benzylamino)-2-[(3-hydroxypropyl)amino]-9-isopropylpurine, bohemine (13) and Ros = 6-(benzylamino)-2-[(1-hydroxymethylpropyl)amino]-9-isopropylpurine, roscovitine (14), have been prepared. They have been fully characterized by microanalysis, conductivity, FT-IR, H-1, C-13, N-15 and Pt-195 NMR and ES+ mass spectroscopy. All of the compounds have been tested in vitro for their cytotoxicity against four human cancer cell lines. The molecular structures of two ionic pair compounds (BohH)(2)(2+))[PtCl6].H2O and (RosH(2)(2+))(2)[PtCl6]Cl2.4H2O have been determined by a single crystal X-raz analysis.

  • Czech name

    První platičité komplexy obsahující aromatické cytokininy nebo inhibitory cyklin-dependentních kináz odvozené od 6-benzylaminopurinu: Molekulové struktury (BohH(2)(2+))[PtCl6].H2O a (RosH(2)(2+)(2)[PtCl6]Cl2.4H2O

  • Czech description

    Série platičitých komplexů s cytokininy nebo inhibitory CDK odvozenými 6-benzylaminopurinu (Bap) o složení [Pt-IV(LH+)Cl-5] (1-14), kde LH+ je protonizovaná forma derivátu bap (1-12), Boh = 6-(benzylamino)-2-[(3-hydroxypropyl)amino]-9-isopropylpurin, bohemin (13) a Ros = 6-(benzylamino)-2-[(1-hydroxymethylpropyl)amino]-9-izopropylpurin, roskovitin (14), byly připraveny a plně charakterizovány pomocí mikroanalýzy, vodivostních měření, FT-IR, H-1, C-13, N-15 a Pt-195 NMR a ES+ hmotnostní spektrometrií. Všechny sloučeniny byly testovány in vitro na cytotoxicitu na čtyřech lidských nádorových liniích. Molekulové struktury dvou iontových sloučenin (BohH)(2)(2+))[PtCl6].H2O a (RosH(2)(2+))(2)[PtCl6]Cl2.4H2O byly určeny pomocí monokrystalové rentgenostrukturní analýzy.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CA - Inorganic chemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2007

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Polyhedron

  • ISSN

    0277-5387

  • e-ISSN

  • Volume of the periodical

    26

  • Issue of the periodical within the volume

    18

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    12

  • Pages from-to

    5271-5282

  • UT code for WoS article

  • EID of the result in the Scopus database