Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F07%3A00005564" target="_blank" >RIV/61989592:15310/07:00005564 - isvavai.cz</a>

Alternative codes found

RIV/61389030:_____/08:00322284 RIV/61989592:15310/08:00010328

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Novel potent inhibitors of A. thaliana cytokinin oxidase/dehydrogenase

Original language description

The synthesis of a new group of 2-X-6-anilinopurines, including compounds with potential cytokinin-like activities, with various substitutions (X = H, halogen, amino, methylthio or nitro) on the phenyl ring is described. The prepared compounds have beencharacterized using standard physico-chemical methods, and the influence of individual substituents on biological activity has been compared in three different bioassays, based on the stimulation of tobacco callus growth, retention of chlorophyll in excised wheat leaves and the dark induction of betacyanin synthesis in Amaranthus cotyledons. The biological activity of the prepared compounds was also assessed in receptor assays, in which the ability of the compounds to activate the cytokinin receptors AHK3 and AHK4/CRE1 was studied. Finally, the interactions of the compounds with the Arabidopsis cytokinin oxidase/dehydrogenase AtCKX2 (heterologously expressed) were investigated. Systematic testing led to the identification of two very po

Czech name

Nové účinné inhibitory cytokinin oxydázy/dehydrogenázy A. thaliana

Czech description

6-anilinopuriny byly připraveny a popsány jako nová skupina účinných inhibitorů enzymu degardace rostlinných hormonů cytokininů. Byla popsána základní biologická aktivita a vztah mezi strukturou a aktivitou připravených látek.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioorganic & Medicinal Chemistry

ISSN

0968-0896

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

20

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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