Novel iron complexes bearing N6-substituted adenosine derivatives: Synthesis, magnetic, 57Fe Mössbauer, DFT, and in vitro cytotoxicity studies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F08%3A00005557" target="_blank" >RIV/61989592:15310/08:00005557 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Novel iron complexes bearing N6-substituted adenosine derivatives: Synthesis, magnetic, 57Fe Mössbauer, DFT, and in vitro cytotoxicity studies
Original language description
Iron complexes (1-7) involving N6-benzyladenosine derivatives of the predominant composition [Fe(Ln)Cl3] center dot H2O {where L1 = N6-(2-fluorobenzyl)adenosine (1), L2 = N6-(4-fluorobenzyl)adenosine (2), L3 = N6-(2-trifluoromethylbenzyl)adenosine (3), L4 = N6-(3-trifluoromethylbenzyl)adenosine (4), L5 = N6-(4-trifluoromethylbenzyl)adenosine (5), L6 = N6-(4-trifluoromethoxybenzyl)adenosine (6), and L7 = N6-(4-chlorobenzyl)adenosine (7)} have been synthesized. The compounds have been characterized by elemental analysis, variable-temperature and in-field 57Fe Mössbauer, ES+ MS, FTIR, 1H and 13C NMR spectroscopies, magnetochemical and conductivity measurements, thermal (TGA/DSC/DTA) analyses, and DFT calculations. It has been found that the organic molecule is coordinated to iron via N7 atom of the appropriate adenosine derivative and the products are represented by mixtures of complexes with various iron oxidation (FeIII/FeII) and spin states (S = 5/2, 4/2, 3/2, 2/2) and geometries (tetr
Czech name
Nové komplexy železa s N6-substituovanými deriváty adenosinu: Syntéza, magnetické vlastnosti, 57Fe Mössbauerova spektroskopie, DFT a studium in vitro cytotoxicity
Czech description
Byly připraveny komplexy železa obsahující deriváty od N6-benzyladenosinu o složení [Fe(Ln)Cl3] H2O {L1 = N6-(2-fluorobenzyl)adenosin (1), L2 = N6-(4-fluorobenzyl)adenosin (2), L3 = N6-(2-trifluoromethylbenzyl)adenosin (3), L4 = N6-(3-trifluoromethylbenzyl)adenosin (4), L5 = N6-(4-trifluoromethylbenzyl)adenosin (5), L6 = N6-(4-trifluoromethoxybenzyl)adenosin (6), and L7 = N6-(4-chlorobenzyl)adenosin (7)}. Sloučeniny byly charakterizovány pomocí elementárních analýz, 57Fe Mössbauer. spektroskopie, ES+ MS, FTIR, 1H and 13C NMR spectroskopie, magnetochemického a vodivostního měření, termických (TGA/DSC/DTA) analýz a DFT výpočtů. Sloučeniny byly také testovány pro jejich in vitro cytotoxicitu proti rakovině následujících lidských buněčných linií: maligní melanom (G-361), osteogenní sarkom (HOS), chronická myeloidní leukémie (K-562) a adenokarcinom prsu (MCF-7).
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioorganic & Medicinal Chemistry
ISSN
0968-0896
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
18
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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