Nitrace proteinů reaktivními formami dusíku

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F09%3A00010352" target="_blank" >RIV/61989592:15310/09:00010352 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Nitrace proteinů reaktivními formami dusíku
Original language description
This review summarizes the current knowledge of nitration of tyrosine residues in proteins. Tyrosine residues are nitrated to 3-nitrotyrosine residues by reactive compounds like nitric oxide, nitric dioxide, peroxynitrite and nitrite metabolites as wellas by other reactive nitrogen and oxygen species. Peroxynitrites are probably the most important nitration agents in vivo, though other nitrations have also been described. The introduced nitro group influences pKa of the tyrosine residue and its accessibility to phosphorylation as well as protein structure, stability and biological activity. The enhanced nitration of proteins is a consequence of a higher production of reactive nitrogen and oxygen species and/or their lower scavenging. Nitrated proteinsare observed in many cardiovascular, neurodegenerative and inflammatory pathologies. The nitrated proteins can be detected by immunohistochemical methods in situ or detected and identified by chromatography and mass spectrometry.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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