Nanoelectrospray versus electrospray in chiral analysis by the kinetic method

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F09%3A00010408" target="_blank" >RIV/61989592:15310/09:00010408 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Nanoelectrospray versus electrospray in chiral analysis by the kinetic method

Original language description

Electrospray ionization generates trimeric diastereoisomeric clusters as the first important step in chiral analysis by mass spectrometry using the Cooks' kinetic method. Cu2+ and L-tryptophan were used as a central metal and as a chiral reference ligand, respectively. The comparison of electrospray and nanoelectrospray showed that although the electrospray system was generally more robust, the application of nanoelectrospray was essential for performing successful analysis in some cases, especially forreal samples. Basically, no significant differences between the ion sources were observed for model samples of analytes (isoleucine, ephedrine, phenylalanine) without interfering matrix. On the other hand, model samples containing sodium chloride and abuffer containing a real sample (drug formulation Mucoseptonex E in which D-ephedrine is the active substance) could not be analyzed using ESI, whereas nano-ESI gave satisfactory results. An explanation is based on the differences of ioni

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

<a href="/en/project/GA203%2F07%2F0765" target="_blank" >GA203/07/0765: Analysis of isomers by mass spectrometry and kinetic method</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Collection of Czechoslovak Chemical Communications

ISSN

0010-0765

e-ISSN

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Volume of the periodical

74

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

10

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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