Roscovitine-based CDK inhibitors acting as N-donor ligands in the platinum(II) oxalato complexes: Preparation, characterization and in vitro cytotoxicity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F10%3A10213187" target="_blank" >RIV/61989592:15310/10:10213187 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Roscovitine-based CDK inhibitors acting as N-donor ligands in the platinum(II) oxalato complexes: Preparation, characterization and in vitro cytotoxicity
Original language description
The reactions of potassium bis(oxalato)platinate dihydrate with two molar equivalents of the potent adenine-based cyclin-dependent kinase inhibitor 2-(1-ethyl-2-hydroxyethylamino)-N6-(benzyl)-9-isopropyladenine (Roscovitine: Ros) and its benzyl-substituted analogues were performed and the [Pt(ox)(Ros)(2)] 3/4 H2O (1), [Pt(ox)(2OMeRos)(2)] H2O (2), (Pt(ox)(3OMeR-os)(2)] 1/2H(2)O (3) and [Pt(ox)(4OMeRos)(2)] 3/4 H2O (4) platinum(II) oxalato complexes were obtained. In vitro cytotoxic activity of the complexes against ovarian carcinoma (A2780), cisplatin resistant ovarian carcinoma (A2780cis). malignant melanoma (G-361), lung carcinoma (A549). cervix epitheloid carcinoma (HeLa). breast adenocarcinoma (MCF7) and osteosarcoma (HOS) human cancer cell lines was evaluated.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Medicinal Chemistry
ISSN
0223-5234
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
10
Country of publishing house
FR - FRANCE
Number of pages
6
Pages from-to
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UT code for WoS article
000282112700024
EID of the result in the Scopus database
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