Palladium(II) oxalato complexes involving N6-(benzyl)-9-isopropyladenine-based N-donor carrier ligands: Synthesis, general properties, H-1, C-13 and N-15{H-1} NMR characterization and in vitro cytotoxicity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F10%3A10213241" target="_blank" >RIV/61989592:15310/10:10213241 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Palladium(II) oxalato complexes involving N6-(benzyl)-9-isopropyladenine-based N-donor carrier ligands: Synthesis, general properties, H-1, C-13 and N-15{H-1} NMR characterization and in vitro cytotoxicity
Original language description
A series of seven palladium(II) oxalato (ox) complexes of the general formula [Pd(ox)(L1-7)(2)].nH(2)O (1-7; n = 0 for 4, 5 and 7, (3)/(4) for 1 and 2, 1 for 6, and 3 for 3) has been prepared. The compounds were characterized by elemental analysis, IR, Raman, H-1, C-13 and N-15{H-1} NMR spectroscopy, ESI+ mass spectrometry, molar conductivity and TG/DTA thermal analysis. The geometry of [Pd(ox)(L-2)(2)] (2) was optimized on the B3LYP/6-311G*/LANL2DZ level of theory. The complexes 4-7 represent the firstpalladium(II) oxalato complexes with a PdN2O2 donor set, which involve highly potent purine-based cyclin-dependent kinase (CDK) inhibitors (L4-7) as carrier N-donor ligands. The selected complexes 1, 3-5 and 7 were tested by an MTT assay for their in vitro cytotoxic activity against human osteosarcoma (HOS) cancer cell line.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Inorganica Chimica Acta
ISSN
0020-1693
e-ISSN
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Volume of the periodical
363
Issue of the periodical within the volume
7
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
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UT code for WoS article
000276190300021
EID of the result in the Scopus database
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