CONTROLLED BAND DISPERSION FOR QUANTITATIVE BINDING DETERMINATION AND ANALYSIS WITH ELECTROSPRAY IONIZATION-MASS SPECTROMETRY

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F10%3A10215676" target="_blank" >RIV/61989592:15310/10:10215676 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

CONTROLLED BAND DISPERSION FOR QUANTITATIVE BINDING DETERMINATION AND ANALYSIS WITH ELECTROSPRAY IONIZATION-MASS SPECTROMETRY

Original language description

This review discusses recent emerging techniques that have been used to couple flow-injection analysis (FIA) and electrospray ionization-mass spectrometry (ESI-MS) for the quantitation of noncovalent binding interactions. Focus is placed predominantly ontwo such methods. Diffusion-based measurements, developed by Konermann and co-workers, uses controlled-band dispersion prior to ESI-MS to determine diffusion constants and binding constants based on the temporal variation of ligand signal measured in the mass spectrum (an indirect technique). Dynamic titration, developed by Schug and co-workers, is a direct method, where a temporal compositional gradient of a guest molecule is induced in the presence of host in solution to monitor the concentration dependence of complex formation as a function of observed complex ion abundance after ESI-MS. Further discussion places these techniques in the context of a variety of other direct and indirect ESI-MS-based binding determination methods.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mass Spectrometry Reviews

ISSN

0277-7037

e-ISSN

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Volume of the periodical

29

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

24

Pages from-to

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UT code for WoS article

000281724300006

EID of the result in the Scopus database

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