Determination of rosiglitazone and metformin in human serum by CE-ESI-MS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F11%3A33117310" target="_blank" >RIV/61989592:15310/11:33117310 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/jssc.201000823" target="_blank" >http://dx.doi.org/10.1002/jssc.201000823</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jssc.201000823" target="_blank" >10.1002/jssc.201000823</a>
Alternative languages
Result language
angličtina
Original language name
Determination of rosiglitazone and metformin in human serum by CE-ESI-MS
Original language description
A new method for the determination of anti-diabetic drugs metformin and rosiglitazone based on the use of capillary electrophoresis with electrospray mass spectrometry was developed. The proposed method allowed their separation within 11 min by using 50mM formic acid at 120 kV. Positive electrospray ionization and selected ion monitoring [M1H]1 of metformin (m/z5130) and rosiglitazone (m/z5358) were performed. Several important experimental parameters influencing electrospray ionization of metformin androsiglitazone were studied. The final composition of sheath liquid was water/methanol/formic acid (50:49.5:0.5, v/v/v), at a flow rate of 2 mL/min. The developed method was applied for the determination of metformin and rosiglitazone simultaneously in human serum after protein precipitation with acetonitrile. The limits of detection of developed method were 4.42 and 2.14 ng/mL for rosiglitazone and for metformin, respectively, which is sufficient for therapeutic serum concentration leve
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED2.1.00%2F03.0058" target="_blank" >ED2.1.00/03.0058: Regional Centre of Advanced Technologies and Materials</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Separation Science
ISSN
1615-9306
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
10
Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
1167-1173
UT code for WoS article
000290635400010
EID of the result in the Scopus database
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