High Performance Liquid Chromatography-Electrochemistry-Electrospray Ionization Mass Spectrometry (HPLC/EC/ESI-MS) for Detection and Characterization of Roscovitine Oxidation Products

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F11%3A33118145" target="_blank" >RIV/61989592:15310/11:33118145 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/11:00374545 RIV/70883521:28610/12:43866427
Result on the web
<a href="http://dx.doi.org/10.1002/elan.201100383" target="_blank" >http://dx.doi.org/10.1002/elan.201100383</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/elan.201100383" target="_blank" >10.1002/elan.201100383</a>

Result language
angličtina
Original language name
High Performance Liquid Chromatography-Electrochemistry-Electrospray Ionization Mass Spectrometry (HPLC/EC/ESI-MS) for Detection and Characterization of Roscovitine Oxidation Products
Original language description
On-line LC-EC/ESI-MS has been established as a fast and simple method to mimic some types of oxidation reaction of various drugs and to study the formation and structure of the resulting products. This technique has been applied to a 2,6,9-trisubstitutedpurine, R-roscovitine, which is known to be an inhibitor of some cyclin-dependent kinases (CDKs) and a potential anticancer drug. Oxidation of R-roscovitine in an electrochemical cell (EC), operated under various conditions, resulted in appearance of 6major products. These were further analyzed by high-resolution mass spectrometry, their structures were elucidated by accurate mass measurement and compared to previously identified R-roscovitine in vitro/in vivo metabolites. Although none of the observed products was structurally identical to those identified previously in vitro/in vivo, all of them, except for the methoxylated products, resembled similarity due to appearing through the same reaction type. R-roscovitine in the EC cell u
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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