Antabuse repurposing: we need more knowledge and wide international support

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F11%3A33118863" target="_blank" >RIV/61989592:15310/11:33118863 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/ijc.25779" target="_blank" >http://dx.doi.org/10.1002/ijc.25779</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ijc.25779" target="_blank" >10.1002/ijc.25779</a>

Result language
angličtina
Original language name
Antabuse repurposing: we need more knowledge and wide international support
Original language description
Antabuse in the human body is metabolized to diethyldithiocarbamate and its derivatives,1 which are quite reactive compounds2 targeting many cellular proteins.3 However, the active compounds in Antabuse-mediated cancer suppression seem to be relatively nonreactive complexes of diethyldithiocarbamate with zinc or copper formed in the body, not Antabuse on its own. That is why Antabuse is tested with copper supplementation in Utah clinical trial (ClinicalTrials.gov Identifier: NCT00742911).
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/GP303%2F08%2FP137" target="_blank" >GP303/08/P137: Influence of dithiocarbamate complexes with Pt(II) and Au(III) on NF-?B pathway in human tumor lines HepG2 and SK-HEP-1</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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