Diethyldithiocarbamate complex with copper: the mechanism of action in cancer cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33141661" target="_blank" >RIV/61989592:15310/12:33141661 - isvavai.cz</a>
Result on the web
<a href="http://benthamscience.com/contents-JCode-MRMC-Vol-00000012-Iss-00000012.htm" target="_blank" >http://benthamscience.com/contents-JCode-MRMC-Vol-00000012-Iss-00000012.htm</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Diethyldithiocarbamate complex with copper: the mechanism of action in cancer cells
Original language description
The idea of "repurposing" of existing drugs provides an effective way to develop and identify new therapies. Disulfiram (Antabuse), a drug commonly used for the treatment of alcoholism, shows promising anticancer activity in both preclinical and clinicalstudies. In the human body, disulfiram is rapidly converted to its reduced metabolite, diethyldithiocarbamate. If copper ions are available, a bis(diethyldithiocarbamate)-copper(II) complex is formed. Disulfiram's selective anticancer activity is attributed to the copper(II) complex's ability to inhibit the cellular proteasome. It is assumed that the complex inhibits the proteasome by a mechanism that is distinct to the clinically used drug bortezomib, targeting the 19S rather than the 20S proteasome.This difference could be explained by inhibition of the JAMM domain of the POH1 subunit within the lid of the 19S proteasome.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/EE.2.3.20.0062" target="_blank" >EE.2.3.20.0062: An inexpensive drug Antabuse as anticancer remedy: mechanism of action and clinical trials</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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