Anticancer Activities of Brassinosteroids
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33119849" target="_blank" >RIV/61989592:15310/12:33119849 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/12:33119849 RIV/61389030:_____/12:00387440
Result on the web
<a href="http://dx.doi.org/10.2174/97816080529811120101" target="_blank" >http://dx.doi.org/10.2174/97816080529811120101</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/97816080529811120101" target="_blank" >10.2174/97816080529811120101</a>
Alternative languages
Result language
angličtina
Original language name
Anticancer Activities of Brassinosteroids
Original language description
Molecular and cellular effects of two groups of antiproliferative agents, natural brassinosteroids (BRs) and their synthetic derivatives, were examined in different human cancer cell lines and in primary endothelial cells in vitro. Natural and syntheticBRs caused growth inhibition, cell cycle arrest and initiation of apoptosis in many different cancer cell lines. The inhibition of proliferation and migration of human endothelial cells by BRs was demonstrated and evidences were obtained that BRs initiate cell death by apoptosis. And, analogues of BRs were found to be more effective than natural BRs. Observed inhibition of migration and tube formation demonstrated the antiangiogenic activity of BRs. These findings indicate a potential use of BRs in theprevention of metastasis development. Investigation of the mechanisms of action of BRs in human cancer and endothelial cells using cellular and molecular techniques indicated the possible involvement of steroid receptors in BR action. How
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
EF - Botany
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Brassinosteroids: Practical Applications in Agriculture and Human Health
ISBN
978-1-60805-298-1
Number of pages of the result
10
Pages from-to
84-93
Number of pages of the book
96
Publisher name
Bentham Science Publishers
Place of publication
Spojené arabské emiráty
UT code for WoS chapter
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