Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33142882" target="_blank" >RIV/61989592:15310/12:33142882 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/12:00388867 RIV/68378050:_____/12:00388867 RIV/61388963:_____/12:00388867
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0039128X12002395" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0039128X12002395</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.steroids.2012.08.011" target="_blank" >10.1016/j.steroids.2012.08.011</a>
Alternative languages
Result language
angličtina
Original language name
Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells
Original language description
Antiangiogenic activity of the brassinosteroid plant hormones (BRs) and their derivative cholestanon was investigated in human umbilical vein endothelial cells (HUVEC) and in human microvascular endothelial cells (HMEC-1). 24-Epibrassinolide and 28-homocastasterone from group of 21 tested natural BRs inhibited migration of HUVEC cells. Seven tested BRs decreased the number of tubes significantly. Synthetic analogue cholestanon inhibited angiogenesis in vitro more effectively than natural BRs. Because ofthe similarity of BRs to human steroids, we have also studied interactions of BRs with human steroid receptors. Synthetic BRs cholestanon showed agonistic effects on estrogen-receptor-alpha, estrogen-receptor-beta and androgen receptor. Of the natural BRs, 24-epibrassinolide was found to be a weak antagonist of estrogen-receptor-alpha (ER alpha). Our results provide the first evidence that large group of BRs can inhibit in vitro angiogenesis of primary endothelial cells. BRs constitute
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Steroids
ISSN
0039-128X
e-ISSN
—
Volume of the periodical
77
Issue of the periodical within the volume
13
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
1502-1509
UT code for WoS article
000312423300024
EID of the result in the Scopus database
—