DNA conformation and repair of polymeric natural DNA damaged by antitumor azolato-bridged dinuclear PtII complex

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33142301" target="_blank" >RIV/61989592:15310/12:33142301 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/12:00381588
Result on the web
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2012.04.015" target="_blank" >http://dx.doi.org/10.1016/j.jinorgbio.2012.04.015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2012.04.015" target="_blank" >10.1016/j.jinorgbio.2012.04.015</a>

Result language
angličtina
Original language name
DNA conformation and repair of polymeric natural DNA damaged by antitumor azolato-bridged dinuclear PtII complex
Original language description
The results demonstrate for the first time that little conformational distortions induced by new antitumor azolato-bridged dinuclear PtII complexes, such as [{cis-Pt(NH3)2}2(?-OH)(?-pyrazolate)]2+ in highly polymeric DNA with a random nucleotide sequencerepresent a structural motif recognizable by DNA repair systems less efficiently than distortions induced by cisplatin. Thus, DNA adducts of azolato-bridged dinuclear PtII complexes can escape repair mechanisms more easily than those of cisplatin, whichmay potentiate antitumor effects of these new metallodrugs in cancer cells.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)