Antitumor carboplatin is more toxic in tumor cells when photoactivated: enhanced DNA binding

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33142315" target="_blank" >RIV/61989592:15310/12:33142315 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00775-012-0906-z" target="_blank" >http://dx.doi.org/10.1007/s00775-012-0906-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00775-012-0906-z" target="_blank" >10.1007/s00775-012-0906-z</a>

Result language
angličtina
Original language name
Antitumor carboplatin is more toxic in tumor cells when photoactivated: enhanced DNA binding
Original language description
It was found that carboplatin was converted to species capable of enhanced DNA binding by UVA irradiation and consequently its toxicity in cancer cells was markedly enhanced. Recent advances in laser and fiber-optic technologies make it possible to irradiate also internal organs with light of highly defined intensity and wavelength. Thus, carboplatin is a candidate for use in photoactivated cancer chemotherapy
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—

Project
<a href="/en/project/GD301%2F09%2FH004" target="_blank" >GD301/09/H004: Molecular and structural biology of selected antitumor drugs. From mechanistic studies to chemotherapy of tumors</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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