Antitumor bifunctional dinuclear Pt-II complex BBR3535 forms interduplex DNA cross-links under molecular crowding conditions

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33142319" target="_blank" >RIV/61989592:15310/12:33142319 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/12:00386048
Result on the web
<a href="http://dx.doi.org/10.1007/s00775-011-0845-0" target="_blank" >http://dx.doi.org/10.1007/s00775-011-0845-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00775-011-0845-0" target="_blank" >10.1007/s00775-011-0845-0</a>

Result language
angličtina
Original language name
Antitumor bifunctional dinuclear Pt-II complex BBR3535 forms interduplex DNA cross-links under molecular crowding conditions
Original language description
The interduplex cross-linking capability of a representative of antitumor polynuclear agents, namely, dinuclear PtII complex [{trans-PtCl(NH3)2}2-?-{trans-(H2N(CH2)6NH2(CH2)2NH2(CH2)6NH2)}]4+ (BBR3535) was examined. The investigations were conducted under molecular crowding conditions mimicking environmental conditions in the cellular nucleus. It was demonstrated that the production of interduplex cross-links in addition to other DNA intramolecular adducts may provide polynuclear PtII compounds with a wider spectrum of cytotoxicity.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—

Project
<a href="/en/project/ME10066" target="_blank" >ME10066: Transition metal-based anticancer compounds. From mechanistic studies to innovatory cancer chemotherapy</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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