Factors affecting DNA-DNA interstrand cross-links in the antiparallel 3'-3' sense: A comparison with the 5'-5' directional isomer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F09%3A00010122" target="_blank" >RIV/61989592:15310/09:00010122 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/09:00330736

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Factors affecting DNA-DNA interstrand cross-links in the antiparallel 3'-3' sense: A comparison with the 5'-5' directional isomer

Original language description

Reported herein is a study of the unusual 3'-3' 1,4-GG interstrand cross-link (IXL) formation in duplex DNA by a series of polynuclear platinum anticancer complexes. To examine the effect of possible preassociation through charge and hydrogen-bonding effects the closely related compounds [{trans-PtCl(NH3)2}2(-trans-Pt(NH3)2-{NH2 (CH2)6NH2}2)]4+ (BBR3464, 1), [{trans-PtCl (NH3)2}2 (-NH2 (CH2)6-NH2)]2+ (BBR3005, 2), [{trans-PtCl(NH3)2}2(-H2N (CH2)3NH2 (CH2)4)]3+ (BBR3571, 3) and [{trans-PtCl (NH3)2}2-{-H2N (CH2)3N (COCF3) (CH2)4}]2+ (BBR3571-COCF3, 4) were studied. Two different molecular biology approaches were used to investigate the effect of DNA template upon IXL formation in synthetic 20-base-pair duplexes. In the "hybridisation directed" method themonofunctionally adducted top strands were hybridised with their complementary 5'-end labelled strands; after 24 h the efficiency of interstrand cross-linking in the 5'-5' direction was slightly higher than in the 3

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemistry: A European Journal

ISSN

0947-6539

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

37

Country of publishing house

DE - GERMANY

Number of pages

10

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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