Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second-generation antitumor dinuclear Pt-II complexes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F12%3A00389601" target="_blank" >RIV/68081707:_____/12:00389601 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00775-011-0841-4" target="_blank" >http://dx.doi.org/10.1007/s00775-011-0841-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00775-011-0841-4" target="_blank" >10.1007/s00775-011-0841-4</a>
Alternative languages
Result language
angličtina
Original language name
Thermodynamic stability and energetics of DNA duplexes containing major intrastrand cross-links of second-generation antitumor dinuclear Pt-II complexes
Original language description
The effects of major DNA intrastrand cross-links of antitumor dinuclear Pt-II complexes [{trans-PtCl(NH3)(2)}(2)-mu-{trans-(H2N(CH2)(6)NH2(CH2)(2)NH2(CH2)(6) NH2)}](4+) (1) and [{PtCl(DACH)}(2)-mu-{H2N(CH2)(6)NH2 (CH2)(2)NH2(CH2)(6)NH2)}](4+) (2) (DACH is 1,2-diaminocyclohexane) on DNA stability were studied with emphasis on thermodynamic origins of that stability. Oligodeoxyribonucleotide duplexes containing the single 1,2, 1,3, or 1,5 intrastrand cross-links at guanine residues in the central TGGT, TGTGT, or TGTTTGT sequences, respectively, were prepared and analyzed by differential scanning calorimetry. The unfolding of the platinated duplexes was accompanied by unfavorable free energy terms.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biological Inorganic Chemistry
ISSN
0949-8257
e-ISSN
—
Volume of the periodical
17
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
187-196
UT code for WoS article
000301185800003
EID of the result in the Scopus database
—