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A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464.

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F02%3A17023025" target="_blank" >RIV/68081707:_____/02:17023025 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14310/02:00007654

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464.

  • Original language description

    The DNA binding profiles of three bis Pt(II) polyamine-linked compounds, [{trans-PtCl(NH3)(2)}(2) {mu-spermine-N-1,N-12}](4+), [{trans-PtCl(NH3)(2)}(2){mu-spermidine-N-1,N-8}](3+) and [{trans-PtCl(NH3)(2)}(2){mu-BOC-spermidine}](2+), were compared with that of a novel trinuclear phase II clinical agent, [{trans-PtCl(NH3)(2)}(2){mu-trans-Pt(NH3)(2)(H2N(CH2)(6)NH2)(2)}](4+). All of the compounds bind preferentially in a bifunctional manner, according to unwinding of supercoiled DNA circles. The kinetics of binding of these compounds corresponds to their relative charge (2 + to 4 +). The preference for the formation of interstrand crosslinks, however, does not follow a charge-based pattern. By studying the results of DNA polymerase extension products on aDNA template modified by the compounds, and by incorporating the complementary method of RNA transcription mapping, it was possible to determine the nucleotide bases that are preferred sites of binding.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2002

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Biological Inorganic Chemistry

  • ISSN

    0949-8257

  • e-ISSN

  • Volume of the periodical

    7

  • Issue of the periodical within the volume

    4/5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    397-404

  • UT code for WoS article

  • EID of the result in the Scopus database