A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F02%3A17023025" target="_blank" >RIV/68081707:_____/02:17023025 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/02:00007654
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
A comparison of DNA binding profiles of dinuclear platinum compounds with polyamine linkers and the trinuclear platinum phase II clinical agent BBR3464.
Original language description
The DNA binding profiles of three bis Pt(II) polyamine-linked compounds, [{trans-PtCl(NH3)(2)}(2) {mu-spermine-N-1,N-12}](4+), [{trans-PtCl(NH3)(2)}(2){mu-spermidine-N-1,N-8}](3+) and [{trans-PtCl(NH3)(2)}(2){mu-BOC-spermidine}](2+), were compared with that of a novel trinuclear phase II clinical agent, [{trans-PtCl(NH3)(2)}(2){mu-trans-Pt(NH3)(2)(H2N(CH2)(6)NH2)(2)}](4+). All of the compounds bind preferentially in a bifunctional manner, according to unwinding of supercoiled DNA circles. The kinetics of binding of these compounds corresponds to their relative charge (2 + to 4 +). The preference for the formation of interstrand crosslinks, however, does not follow a charge-based pattern. By studying the results of DNA polymerase extension products on aDNA template modified by the compounds, and by incorporating the complementary method of RNA transcription mapping, it was possible to determine the nucleotide bases that are preferred sites of binding.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biological Inorganic Chemistry
ISSN
0949-8257
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
4/5
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
397-404
UT code for WoS article
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EID of the result in the Scopus database
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