Interactions of DNA with a new platinum(IV) azide dipyridine complex activated by UVA and visible light: Relationship to toxicity in tumor cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33142324" target="_blank" >RIV/61989592:15310/12:33142324 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/12:00381594
Result on the web
<a href="http://dx.doi.org/10.1021/tx300057y" target="_blank" >http://dx.doi.org/10.1021/tx300057y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/tx300057y" target="_blank" >10.1021/tx300057y</a>
Alternative languages
Result language
angličtina
Original language name
Interactions of DNA with a new platinum(IV) azide dipyridine complex activated by UVA and visible light: Relationship to toxicity in tumor cells
Original language description
The PtIV diazido complex trans,trans,trans-[Pt(N3)2(OH)2(pyridine)2] (1) is unreactive in the dark but is cytotoxic when photoactivated by UVA and visible light. Complex 1 when photoactivated accumulates in tumor cells and binds strongly to nuclear DNA under conditions in which it is toxic to tumor cells. DNA adducts of 1 could trigger a number of downstream cellular effects different from those triggered in cancer cells by DNA adducts of cisplatin. This might lead to the therapeutic effects that couldradically improve chemotherapy by platinum complexes. The findings of the present work provide new insights into mechanisms associated with the antitumor effects of platinum complexes photoactivated by UVA and visible light.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Chemical Research in Toxicology
ISSN
0893-228X
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
1099-1111
UT code for WoS article
000304235000013
EID of the result in the Scopus database
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