Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F16%3A00461985" target="_blank" >RIV/68081707:_____/16:00461985 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15310/16:33161146
Result on the web
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2015.12.029" target="_blank" >http://dx.doi.org/10.1016/j.jinorgbio.2015.12.029</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2015.12.029" target="_blank" >10.1016/j.jinorgbio.2015.12.029</a>

Result language
angličtina
Original language name
Photo-induced DNA cleavage and cytotoxicity of a ruthenium(II) arene anticancer complex
Original language description
We report DNA cleavage by ruthenium(II) arene anticancer complex [(eta(6)-p-terp)Ru-II(en)Cl](+) (p-terp = paraterphenyl, en = 1,2-diaminoethane, complex 1) after its photoactivation by UVA and visible light, and the toxic effects of photoactivated 1 in cancer cells. It was shown in our previous work (T. Bugarcic et al., J. Med. Chem. 51 (2008) 5310-5319) that this complex exhibits promising toxic effects in several human tumor cell lines and concomitantly its DNA binding mode involves combined intercalative and monofunctional (coordination) binding modes. We demonstrate in the present work that when photoactivated by UVA or visible light, 1 efficiently photocleaves DNA, also in hypoxic media. Studies of the mechanism underlying DNA cleavage by photoactivated 1 reveal that the photocleavage reaction does not involve generation of reactive oxygen species (ROS), although contribution of singlet oxygen (O-1(2)) to the DNA photocleavage process cannot be entirely excluded. Notably, the mechanism of DNA photocleavage by 1 appears to involve a direct modification of mainly those guanine residues to which 1 is coordinatively bound.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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