Platinum-DNA interstrand crosslinks: Molecular determinants of bending and unwinding of the double helix

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33142325" target="_blank" >RIV/61989592:15310/12:33142325 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/12:00057206
Result on the web
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2011.09.025" target="_blank" >http://dx.doi.org/10.1016/j.jinorgbio.2011.09.025</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2011.09.025" target="_blank" >10.1016/j.jinorgbio.2011.09.025</a>

Result language
angličtina
Original language name
Platinum-DNA interstrand crosslinks: Molecular determinants of bending and unwinding of the double helix
Original language description
Platinum diamine complexes are able to crosslink the guanines of d(GC)2 dinucleotides within double-stranded DNA. The interstrand crosslink thus formed causes a bend of the double helix toward the minor groove and the helical sense changes locally to left-handed, resulting in a considerable unwinding. We have used molecular dynamics simulations to investigate the DNA 20-mer containing interstrand cross-link of cis-Pt(NH3)22+, Pt(R,R-DACH)2+, or Pt(S,S-DACH)2+. Molecular determinants of bending and unwinding of the DNA double helix have been determined.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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