A paradigm for AhR-mediated alleviation of type 1 diabetes mellitus pathology by isoquinoline alkaloid berberine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F12%3A33142414" target="_blank" >RIV/61989592:15310/12:33142414 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0308814612001896" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0308814612001896</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.foodchem.2012.02.024" target="_blank" >10.1016/j.foodchem.2012.02.024</a>
Alternative languages
Result language
angličtina
Original language name
A paradigm for AhR-mediated alleviation of type 1 diabetes mellitus pathology by isoquinoline alkaloid berberine
Original language description
Berberine is a constituent of many traditional herbal remedies. However, its anti-inflammatory effect is still unclear and it probably involves multiple mechanisms. Several years ago, we demonstrated that berberine is an activator of aryl hydrocarbon receptor (AhR) in human and rodent hepatoma cell lines (Vrzal et al., 2005). We described an induction of CYP1A1 mRNA and protein, nuclear translocation of AhR-GFP chimeric construct and trans-activation of xenobiotic-responsive element in gene reporter assays, upon treatment with berberine. For this reason, we propose here an involvement of AhR in the in vivo effects of berberine, described in paper by Chueh and Lin.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centre of drug-dietary supplements interactions and nutrigenetics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Food Chemistry
ISSN
0308-8146
e-ISSN
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Volume of the periodical
133
Issue of the periodical within the volume
4
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
2
Pages from-to
1671-1672
UT code for WoS article
000303847400077
EID of the result in the Scopus database
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