Transcriptional Regulation of Human Drug-Metabolizing Cytochrome P450 Enzymes

Result code in IS VaVaI
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Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Transcriptional Regulation of Human Drug-Metabolizing Cytochrome P450 Enzymes
Original language description
Regulation of drug-metabolizing cytochromes P450 (CYPs) occurs via multiple mechanisms. A pivotal means of CYP regulation is transcriptional control, which influences the expression and the amount of the enzyme. Many xenobiotics, including therapeutically used drugs, upregulate (induce) the expression of CYPs by transcriptional mechanisms. Xenobiotic-mediated induction of CYPs results in altered intermediary metabolism as well as the metabolism of drugs and it is, hence, a serious cause of drug-drug interactions. The current chapter summarizes our knowledge on the transcriptional regulation of drug-inducible CYPs comprising CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2Cs, and CYP3A4 genes. The role of pregnane X receptor, constitutive androstane receptor, aryl hydrocarbon receptor, steroid receptors (glucocorticoid receptor, estrogen receptor), nuclear receptors (vitamin D receptor, retinoic X receptor, liver X receptor) and transcriptional factors (HNF-4, C/EBP, SMRT, etc.) is explaine
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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