Antioxidant, metal-binding and DNA-damaging properties of flavonolignans: A joint experimental and computational highlight based on 7-O-galloylsilybin

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33144010" target="_blank" >RIV/61989592:15310/13:33144010 - isvavai.cz</a>

Alternative codes found

RIV/61388971:_____/13:00395322 RIV/61989592:15110/13:33144010

Result on the web

<a href="http://dx.doi.org/10.1016/j.cbi.2013.07.006" target="_blank" >http://dx.doi.org/10.1016/j.cbi.2013.07.006</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Antioxidant, metal-binding and DNA-damaging properties of flavonolignans: A joint experimental and computational highlight based on 7-O-galloylsilybin

Original language description

Besides the well-known chemoprotective effects of polyphenols, their prooxidant activities via interac- tions with biomacromolecules as DNA and proteins are of the utmost importance. Current research focuses not only on natural polyphenols but also on synthetically prepared analogs with promising bio-logical activities. In the present study, the antioxidant and prooxidant properties of a semi-synthetic flavonolignan 7-O-galloylsilybin (7-GSB) are described. The presence of the galloyl moiety significantly enhances the antioxidant capacity of 7-GSB compared to that of silybin (SB). These findings were supported by electrochemistry, DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activity, total antioxidant capacity (CL-TAC) and DFT (density functional theory) calculations. A three-step oxidation mechanism of 7-GSB is proposed at pH 7.4, in which the galloyl moiety is first oxidized at Ep,1= +0.20 V (vs. Ag/AgCl 3M KCl) followed by oxidation of the 20-OH (Ep,2 = +0.55 V) and most probabl

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemico-Biological Interactions

ISSN

0009-2797

e-ISSN

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Volume of the periodical

205

Issue of the periodical within the volume

3

Country of publishing house

IE - IRELAND

Number of pages

8

Pages from-to

173-180

UT code for WoS article

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EID of the result in the Scopus database

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