Direct high-performance liquid chromatographic enantioseparation of free alpha-, beta- and gamma-aminophosphonic acids employing cinchona-based chiral zwitterionic ion exchangers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33147292" target="_blank" >RIV/61989592:15310/13:33147292 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00216-013-6938-6" target="_blank" >http://dx.doi.org/10.1007/s00216-013-6938-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00216-013-6938-6" target="_blank" >10.1007/s00216-013-6938-6</a>
Alternative languages
Result language
angličtina
Original language name
Direct high-performance liquid chromatographic enantioseparation of free alpha-, beta- and gamma-aminophosphonic acids employing cinchona-based chiral zwitterionic ion exchangers
Original language description
We report a chiral high-performance liquid chromatographic enantioseparation method for free alpha-aminophosphonic, beta-aminophosphonic, and gamma-aminophosphonic acids, aminohydroxyphosphonic acids, and aromatic aminophosphinic acids with different substitution patterns. Enantioseparation of these synthons was achieved by means of high-performance liquid chromatography on CHIRALPAK ZWIX(+) and ZWIX(-) (cinchona-based chiral zwitterionic ion exchangers) under polar organic chromatographic elution conditions. Mobile phase characteristics such as acid-to-base ratio, type of counterion, and solvent composition were systematically varied in order to investigate their effect on the separation performance and to achieve optimal separation conditions for theset of analytes. Under the optimized conditions, 32 of 37 racemic aminophosphonic acids studied reached baseline separation when we employed a single generic mass-spectrometry-compatible mobile phase, with reversal of the elution order w
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED2.1.00%2F03.0058" target="_blank" >ED2.1.00/03.0058: Regional Centre of Advanced Technologies and Materials</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Analytical and Bioanalytical Chemistry
ISSN
1618-2642
e-ISSN
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Volume of the periodical
405
Issue of the periodical within the volume
25
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
8027-8038
UT code for WoS article
000324587400010
EID of the result in the Scopus database
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