High-performance liquid chromatographic separation of unusual beta(3)-amino acid enantiomers in different chromatographic modes on Cinchona alkaloid-based zwitterionic chiral stationary phases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156862" target="_blank" >RIV/61989592:15310/15:33156862 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs00726-015-2006-1" target="_blank" >http://link.springer.com/article/10.1007%2Fs00726-015-2006-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00726-015-2006-1" target="_blank" >10.1007/s00726-015-2006-1</a>

Result language
angličtina
Original language name
High-performance liquid chromatographic separation of unusual beta(3)-amino acid enantiomers in different chromatographic modes on Cinchona alkaloid-based zwitterionic chiral stationary phases
Original language description
Polar-ionic and hydro-organic mobile phase mode of high-performance liquid chromatographic separations of 23 sterically constrained primary beta(3)-amino acid enantiomers containing, alkyl, aryl or heteroaryl side-chains were carried out by using newly developed Cinchona alkaloid-based zwitterionic chiral selectors and the stationary phases Chiralpak ZWIX(+)(TM) and ZWIX(-)(TM). In the polar-ionic mode, the effects of the composition of the bulk solvent and the natures of the co- and counter-ions, whilein the hydro-organic mode, the effects of the pH, the counter-ion concentration and the structures of the analytes were investigated. The separations of the enantiomers of these 23 primary beta(3)-amino acids, which can be classified as a series of quasi- (pseudo-) homologs, were optimized in both chromatographic modes. The elution sequence was determined in most cases and a reversal of elution order on ZWIX(+)(TM) and ZWIX(-)(TM) column was observed. On the basis of this intermolecular
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
<a href="/en/project/LO1305" target="_blank" >LO1305: Development of the center of advanced technologies and materials</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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