Enantiomeric separation of R,S-tolterodine and R,S-methoxytolterodine with negatively charged cyclodextrins by capillary electrophoresis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F13%3A33147348" target="_blank" >RIV/61989592:15310/13:33147348 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/jssc.201200530" target="_blank" >http://dx.doi.org/10.1002/jssc.201200530</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jssc.201200530" target="_blank" >10.1002/jssc.201200530</a>

Result language
angličtina
Original language name
Enantiomeric separation of R,S-tolterodine and R,S-methoxytolterodine with negatively charged cyclodextrins by capillary electrophoresis
Original language description
The methods for separation of R,S-tolterodine and R,S-methoxytolterodine enantiomers using sulfated -, -CD and phosphated--CD by CE in acidic BGE based on Tris/phosphate pH 2.5 buffer were developed. Sulfated - and -CD allow anodic detection while phosphated--CD allows only cathodic detection of the separated enantiomers. The influence of chiral selector (CS)'s concentration as well as the influence of composition and concentration of BGE on resolutions were studied. Reversal migration order of tolterodine and methoxytolterodine enantiomers was observed, when sulfated-- and sulfated--CD were used. The developed methods with all three studied CSs, were validated and compared. All proposed methods enable determination of 0.2% of S-tolterodine as an optical impurity in pills, however the method with phosphated--CD provided lower detection limit, better repeatability of peak areas and migration times, and also lower consumption of CS. Developed method employing phosphated--CD that was appl
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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