Structural properties of CYP2D6: requirements for substrates and inhibitors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33150428" target="_blank" >RIV/61989592:15310/14:33150428 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/14:33150428
Result on the web
<a href="http://www.futuremedicine.com/doi/pdf/10.2217/fmeb2013.13.91" target="_blank" >http://www.futuremedicine.com/doi/pdf/10.2217/fmeb2013.13.91</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/9781780844626" target="_blank" >10.2217/9781780844626</a>
Alternative languages
Result language
angličtina
Original language name
Structural properties of CYP2D6: requirements for substrates and inhibitors
Original language description
CYP450 2D6 is a relatively flexible protein with plastic active site structure, allowing binding with high specificity of many different substrates of various sizes. Presence of a basic nitrogen atom at a distance of 5-7 ? from the site of metabolism isoften found in the structure of typical substrates. After substrate binding, the active site structure is changed, embracing the substrate and fixing it in the optimal position for enzyme reaction. The alleles found in the human population that correspond to CYP450 2D6 variants with decreased enzymatic activity possess changed amino acids which, interestingly, do not directly participate in forming the active site. Instead, they probably take part in maintaining other properties of the enzyme, for example in the formation of solvent or substrate access channels.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GPP303%2F12%2FP019" target="_blank" >GPP303/12/P019: Mechanism of ligand access/egress to/from active site of microsomal drug-metabolising cytochromes P450</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
CYP2D6: Genetics, Pharmacology and Clinical Relevance
ISBN
978-1-78084-462-6
Number of pages of the result
10
Pages from-to
69-78
Number of pages of the book
153
Publisher name
Future Medicine Ltd.
Place of publication
London
UT code for WoS chapter
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