CZE Separation of New Drugs for Treatment of Leukemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33151330" target="_blank" >RIV/61989592:15310/14:33151330 - isvavai.cz</a>

Result on the web

<a href="http://download.springer.com/static/pdf/655/art%253A10.1007%252Fs10337-014-2730-9.pdf?auth66=1421833078_4c4cce957f3fc2e08cce9055fec255b6&ext=.pdf" target="_blank" >http://download.springer.com/static/pdf/655/art%253A10.1007%252Fs10337-014-2730-9.pdf?auth66=1421833078_4c4cce957f3fc2e08cce9055fec255b6&ext=.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10337-014-2730-9" target="_blank" >10.1007/s10337-014-2730-9</a>

Result language

angličtina

Original language name

CZE Separation of New Drugs for Treatment of Leukemia

Original language description

Imatinib, bosutinib, dasatinib, pazopanib, erlotinib, canertinib and vatalanib are new developed anticancer drugs, especially for treatment of leukemia. In this article, a fast and high throughput capillary zone electrophoresis method has been developedand validated for analysis of these new drugs in pharmaceutical formulas. The method can be easily utilized for determination of all the drugs in one run what is advantageous for the quality control in pharmaceutical industry because there is no need forchanging and optimization of separation conditions when changing the analyte. The separation was performed using an uncoated fused silica capillary with 100 mmol L-1 sodium phosphate buffer pH 2.75, voltage of 25 kV, hydrodynamic injection time of 5 s by 50 mbar, and detection at 214 nm. Under these conditions, the analysis took about 8 min. The validation of all the drugs resulted in recoveries in the range of 84-100 %. The method showed to be precise for all the drugs with RSDs of mig

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chromatographia

ISSN

0009-5893

e-ISSN

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Volume of the periodical

77

Issue of the periodical within the volume

21-22

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

1477-1482

UT code for WoS article

000345004800009

EID of the result in the Scopus database

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