Solid-Phase Synthesis of 5-Noranagrelide Derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33151904" target="_blank" >RIV/61989592:15310/14:33151904 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/14:33151904
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Solid-Phase Synthesis of 5-Noranagrelide Derivatives
Original language description
Solid-phase synthesis of 1H-benzo[d]imidazoimidazol-2(3H)-one derivatives employing Fmoc-?-amino acids and nitroaryl fluorides as key building blocks has been developed. The Fmoc-?-amino acids immobilized on Wang resin, equipped with a piperazine carbamate linker, were transformed to o-nitroanilines in two steps. After reduction of the nitro group, the corresponding o-phenylenediamines gave the 2-aminobenzimidazole scaffold by reaction either with cyanogen bromide or Fmoc-NCS. Cleavage from the polymersupport and further cyclization afforded the target compounds. The developed methodology represents a versatile and simple approach for the preparation of various corresponding 1H-benzo[d]imidazoimidazol-2(3H)-ones from large number of commercially available building blocks.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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