Solid-Phase Synthesis of Anagrelide Sulfonyl Analogues

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33151916" target="_blank" >RIV/61989592:15310/14:33151916 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/14:33151916
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Solid-Phase Synthesis of Anagrelide Sulfonyl Analogues
Original language description
Simple solid-phase synthesis of 3,10-dihydro-2H-benzo[e]imidazothiadiazin-2-one 5,5-dioxides is described, with Fmoc-?-amino acids and 2-nitrobenzenesulfonylchlorides (2-NosCls) being the key building blocks. Fmoc-?-amino acids were immobilized on Wang resin and transformed to the corresponding 2-nitrobenzenesulfonamides in two steps. After reduction of the nitro group, Fmoc-thioureas were synthesized followed by cyclization of the 1,2,4-benzothiadiazine-1,1-dioxide scaffold with diisopropylcarbodiimide(DIC). Cleavage of the Fmoc protecting group followed by spontaneous cyclative cleavage gave the target products in excellent crude purity.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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