Synthesis of Lupane-Type Saponins Containing an Unusual alpha-D-Idopyranoside Fragment as Potent Cytotoxic Agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33152499" target="_blank" >RIV/61989592:15310/14:33152499 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/14:00433374
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201402187/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201402187/epdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejoc.201402187" target="_blank" >10.1002/ejoc.201402187</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis of Lupane-Type Saponins Containing an Unusual alpha-D-Idopyranoside Fragment as Potent Cytotoxic Agents
Original language description
A practical method for the preparation of benzoyl protected allyl and benzyl alpha-D-idopyranosides, and D-idopyranosyl trichloroacetimidate, from 1,2,3,4,6-penta-O-acetyl-alpha-D-idopyranose, is described. All derivatives can be prepared on a multigramscale and require only simple chromatographic purification. A concise synthesis of lupane triterpenes bearing an unusual D-idopyranoside fragment is described. All new compounds were evaluated in vitro for their cytotoxic activities. Novel saponins exhibited interesting cytotoxic activity in the micromolar range against human cancer cell lines including T-lymphoblastic leukemia CEM, breast adenocarcinoma MCF7, and cervical carcinoma HeLa, but also against normal human fibroblasts BJ.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Organic Chemistry
ISSN
1434-193X
e-ISSN
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Volume of the periodical
19
Issue of the periodical within the volume
JUL
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
4089-4098
UT code for WoS article
000338018400017
EID of the result in the Scopus database
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