Preparation of new 18a-oleanane alcohols: synthesis, characterization, and cytotoxic activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F10%3A10213231" target="_blank" >RIV/61989592:15110/10:10213231 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Preparation of new 18a-oleanane alcohols: synthesis, characterization, and cytotoxic activity
Original language description
New oleanane alcohols and their acetates were prepared using classical reductive reagents (LiAlH4, NaBH4, and B2H6-DMS). In this research, we also studied the influence of these reagents on the stereoselectivity of reduction. All compounds prepared werefully characterized by 1H and 13C NMR spectra, IR spectra, MS, and elemental analysis. These products were tested for cytotoxic activity against T-lymphoblastic leukemia (CEM), human erythromyeloblastoid leukemia (K562), and human melanoma (SK-MEL1) celllines. One of the compounds prepared exhibits significant cytotoxic activity against the mesenchymal type of cancer cell lines.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA305%2F09%2F1216" target="_blank" >GA305/09/1216: Study of mechnism of action and structure optimalization of triterpenoids with anti-tumor activity.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Monatschefte für Chemie
ISSN
0026-9247
e-ISSN
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Volume of the periodical
141
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
12
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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