Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F14%3A33152523" target="_blank" >RIV/61989592:15310/14:33152523 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/14:00429983 RIV/00209805:_____/14:#0000508
Result on the web
<a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089228" target="_blank" >http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089228</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0089228" target="_blank" >10.1371/journal.pone.0089228</a>
Alternative languages
Result language
angličtina
Original language name
Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy
Original language description
CDKs are key regulators of the cell cycle and RNA polymerase II mediated transcription. Several pharmacol. CDK inhibitors are currently in clinical trials as potential cancer therapeutics and some of them also exhibit antiviral effects. Olomoucine II androscovitine, purine-based inhibitors of CDKs, were described as effective antiviral agents that inhibit replication of a broad range of wild type human viruses. Olomoucine II and roscovitine show high selectivity for CDK7 and CDK9, with important functions in the regulation of RNA polymerase II transcription. RNA polymerase II is necessary for viral transcription and following replication in cells. We analyzed the effect of inhibition of CDKs by olomoucine II on gene expression from viral promoters andcompared its effect to widely-used roscovitine. We found that both roscovitine and olomoucine II blocked the phosphorylation of RNA polymerase II C-terminal domain. However the repression of genes regulated by viral promoters was strongl
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS One
ISSN
1932-6203
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
"e89228"
UT code for WoS article
000331717900066
EID of the result in the Scopus database
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