The non-innocent nature of graphene oxide as a theranostic platform for biomedical applications and its reactivity towards metal-based anticancer drugs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33155615" target="_blank" >RIV/61989592:15310/15:33155615 - isvavai.cz</a>
Result on the web
<a href="http://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra13831k" target="_blank" >http://pubs.rsc.org/en/content/articlepdf/2015/ra/c5ra13831k</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c5ra13831k" target="_blank" >10.1039/c5ra13831k</a>

Result language
angličtina
Original language name
The non-innocent nature of graphene oxide as a theranostic platform for biomedical applications and its reactivity towards metal-based anticancer drugs
Original language description
The self-assembly process in a solution of a mononuclear iron(II) complex based on the bispyrazolylpyridine scaffold with graphene oxide (GO) micrometer-sheets allows not only the devising of a new hybrid-architecture for GO-based materials suitable fornanomedicine, but also the unveiling of the reactive nature of GO as a drug-carrier. The neat iron complex is found to be highly active in disrupting the cell cycle through DNA binding, with behaviour and efficiency similar to that expressed by ruthenium-complexes as well as antibiotic-drugs such as doxorubicin. On the contrary, in the hybrid material the proclivity of neat GO to produce reactive oxygen species (ROS) became down-regulated by the electron-buffering properties of the loaded iron complex,evidencing the presence of an active electron transfer from the drug to GO. These findings question the use of the neat GO platform as a suitable carrier for metal-based anticancer drugs and highlight the importance of addressing the chem
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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