Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F14%3A00424588" target="_blank" >RIV/61389013:_____/14:00424588 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1039/C3PY01376F" target="_blank" >http://dx.doi.org/10.1039/C3PY01376F</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/C3PY01376F" target="_blank" >10.1039/C3PY01376F</a>

Result language

angličtina

Original language name

Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers

Original language description

Various click chemistry azide?alkyne cycloaddition reactions were used to attach azide group-terminated peptides to polymer drug carriers in an effort to conjugate biologically active molecules with polymer drug carriers by directly binding unprotected peptides to these polymers. Three methods using click chemistry to conjugate the azide group-containing molecules with synthetic polymers were compared: (1) click chemistry with a Cu(I) catalyst in aqueous and organic solvents, (2) click reactions using ruthenium complex catalysts in DMF and (3) metal-free click chemistry based on a dibenzocyclooctyne (DBCO) reactive group. The suitability of these reactions was verified for the non-covalent attachment of targeting moieties to these polymer carriers viapeptide?peptide interactions. Moreover, RAFT polymerization was suggested for the synthesis of semitelechelic copolymers containing a single DBCO group at the polymer chain end and for the preparation of well-defined diblock copolymer dru

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CD - Macromolecular chemistry

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Polymer Chemistry

ISSN

1759-9954

e-ISSN

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Volume of the periodical

5

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1340-1350

UT code for WoS article

000331343100026

EID of the result in the Scopus database

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