Synthesis, X-ray crystal structure and biological evaluation of zinc(II)-dichlorido complexes with 9-deazahypoxathine derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156165" target="_blank" >RIV/61989592:15310/15:33156165 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0020169315002388" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0020169315002388</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ica.2015.05.013" target="_blank" >10.1016/j.ica.2015.05.013</a>

Result language
angličtina
Original language name
Synthesis, X-ray crystal structure and biological evaluation of zinc(II)-dichlorido complexes with 9-deazahypoxathine derivatives
Original language description
A series of mononuclear zinc(II)-dichlorido complexes of the general formula [Zn(Ln)(2)Cl2].Solv (1-5); n = 1-5, Solv = CH3CN for 1, 2CH(3)CN for 1b, 1/2H2O for complexes 2 and 4; containing 9-deazahypoxanthine derivatives (Ln, 6-(omega-alkyl) oxy-9-deazapurine derivatives) was prepared and thoroughly characterized (by elemental analysis, ESI+ mass spectrometry, FT-IR and multinuclear NMR spectroscopy, and TG/DTA analysis). Single crystal X-ray analysis of [Zn(L1)(2)Cl2].2CH(3)CN (1b) revealed a distorted tetrahedral geometry in the vicinity of the zinc(II) atom with two 6-ethoxy-9-deazapurine molecules (L1) coordinated through the N3 atoms. The complexes were screened for their in vitro antitumor activity against three human cancer cell lines, PC3 andLNCaP (prostate carcinoma), and A2780 (ovarian carcinoma). Moreover, the ability of the complexes to modulate the secretion of interleukin IL-1 beta and matrix metalloproteinase MMP-2 activity on a lipopolysaccharide (LPS)-activated macr
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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