Synthesis, characterization and assesment of the cytotoxic properties of cis- and trans-[Pd(L)2Cl2] complexes involving 6-benzylamino-9-isopropylpurine derivates
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F07%3A00004496" target="_blank" >RIV/61989592:15310/07:00004496 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Synthesis, characterization and assesment of the cytotoxic properties of cis- and trans-[Pd(L)2Cl2] complexes involving 6-benzylamino-9-isopropylpurine derivates
Original language description
A series os square-planar Pd(II) complexes of the compositions cis-[Pd(Ln)2Cl2] {L1 = 2-chloro-6-benzylamino-9-isopropylpurine (1), L2 = 2-chloro-6-[(4-methoxybenzyl)amino]-9-isopropylpurine (2), L3 = 2-chloro-6-[(2-methoxybenzyl)amino]-9-isopropylpurine(3) and 2-[(chloropropyl)amino]-6-benzylamino-9-isopropylpurine (6)} has been synthesized by the reaction of PdCl2 with Ln in a 1:2 molar ratio. In contrast, the same reaction followed by recrystallization of the product from N,N'-dimethylformamide (DMF) leads to trans-[Pd(Ln)Cl2].nDMF {L3, n = 0 (4), n = 1 (4*DMF); L4 = 2-chloro-6-[(2,3-dimethoxybenzyl)-amino]-9-isopropylpurine, n = 0 (5), n = 1.5 (5*DMF). The compounds have been characterized by elemental analyses, conductivity measurements, 1H and 13C NMR spectra and TGA. The molecular structures of trans-[Pd(L3)2Cl2] (4) and trans-[Pd(L4)2Cl2] have been determined by single crystal X-ray analysis. All the comlexes have been tested for their cytotoxicity.
Czech name
Syntéza, charakteristika a určení cytotoxické aktivity komplexů cis- a trans-[Pd(L)2Cl2], které obsahují deriváty 6-benzylamino-9-izopropylpurinu
Czech description
Řada čtvercových palladnatých komplexů o složení cis-[Pd(Ln)2Cl2] {L1 = 2-chloro-6-benzylamino-9-izopropylpurin (1), L2 = 2-chloro-6-[(4-methoxybenzyl)amino]-9-izopropylpurin (2), L3 = 2-chloro-6-[(2-methoxybenzyl)amino]-9-izopropylpurin (3) a 2-[(chloropropyl)amino]-6-benzylamino-9-izopropylpurin (6)} byla připravena reakcí PdCl2 s Ln v molárním poměru 1:2. Naopak, stejná reakce následovaná rekrystalizací produktu z N,N'-dimethylformamidu (DMF) vede k trans-[Pd(Ln)Cl2].nDMF {L3, n = 0 (4), n = 1 (4*DMF); L4 = 2-chloro-6-[(2,3-dimethoxybenzyl)-amino]-9-izopropylpurin, n = 0 (5), n = 1.5 (5*DMF). Sloučeniny byly charakterizovány pomocí elementární analýzy, vodivostních měření, 1H a 13C NMR spekter a TGA. Molekulové struktury trans-[Pd(L3)2Cl2] (4) a trans-[Pd(L4)2Cl2] byly určeny pomocí monokrystalové rengenostrukturní analýzy. Všechny komplexy byly testovány na cytotoxicitu.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA203%2F04%2F1168" target="_blank" >GA203/04/1168: Complexes of selected transition metals with cytokinin derivatives: synthesis, characterization and biological activity</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2007
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Inorganic Biochemistry
ISSN
0162-0134
e-ISSN
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Volume of the periodical
101
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
16
Pages from-to
477-492
UT code for WoS article
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EID of the result in the Scopus database
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