Novel platinum(II) and palladium(II) complexes with cyclin-dependent kinase inhibitors: Synthesis, characterization and antitumour activity.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F06%3A00002623" target="_blank" >RIV/61989592:15310/06:00002623 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/06:00083388
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Novel platinum(II) and palladium(II) complexes with cyclin-dependent kinase inhibitors: Synthesis, characterization and antitumour activity.
Original language description
The Pt(II) and Pd(II) complexes of the types cis-[Pt(L1)2Cl2].H2O (1), cis-[Pt(L2)2Cl2].3H2O (2), trans-[Pd(L1)2Cl2].H2O (3), trans-[Pd(L2)Cl2].H2O (4), trans-[Pd(L3)Cl2].2DMF (5) and trans-[Pd(L4)2Cl2].2DMF (6) (L1-L4=cyclin-dependent kinase inhibitorsderived from 6-benzylamino-9-isopropylpurine) have been prepared and characterized. The complexes have been studied by elemental analyses, conductivity measurements, ES+MS, FT-IR, (1)H, (13)C and (195)Pt spectra, differential scanning calorimetry and thermogravimetric analysis. The molecular structures of L1, trans-[Pd(L3)2Cl2].2DMF (5) and trans-[Pd(L4)2Cl2].2DMF (6) have been determined by single crystal X-ray analysis. The complexes have been tested in vitro due to their presumble anticancer activityagainst the following human cancer cell lines.
Czech name
Nové platnaté a palladnaté komplexy s inhibitory cyklin-dependentních kináz: Příprava, charakteristika a antitumorová aktivita.
Czech description
Platnaté a palladnaté komplexy typu cis-[Pt(L1)2Cl2].H2O (1), cis-[Pt(L2)2Cl2].3H2O (2), trans-[Pd(L1)2Cl2].H2O (3), trans-[Pd(L2)Cl2].H2O (4), trans-[Pd(L3)Cl2].2DMF (5) a trans-[Pd(L4)2Cl2].2DMF (6) (L1-L4=inhibitory cyklin-dependentních kináz odvozených od 6-benzylamino-9-isopropylpurinu) byly připraveny a charakterizovány. Komplexy byly studovány elementární analýzou, vodivostním měřením, ES+MS, FT-IR, (1)H, (13)C a (195)Pt NMR spektroskopií, DSC a termogravimetricou analýzou. Molekulové struktury L1, trans-[Pd(L3)2Cl2].2DMF (5) a trans-[Pd(L4)2Cl2].2DMF (6) byly určeny s pomocí monokrystalové RTG difrakce. Komplexy byly testovány in vitro vzhledem k jejich předpokládané antikancerostatické aktivitě na lidských nádorových liniích.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA203%2F04%2F1168" target="_blank" >GA203/04/1168: Complexes of selected transition metals with cytokinin derivatives: synthesis, characterization and biological activity</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioorganic & Medicinal Chemistry
ISSN
0968-0896
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
479-491
UT code for WoS article
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EID of the result in the Scopus database
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