Synthesis, spectral study and cytotoxicity of platinum(II) complexes with 2,9-disubstituted-6-benzylaminopurines
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F05%3A00001847" target="_blank" >RIV/61989592:15310/05:00001847 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/05:00031136
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Synthesis, spectral study and cytotoxicity of platinum(II) complexes with 2,9-disubstituted-6-benzylaminopurines
Original language description
A series of platinum(II) complexes with 2,9-disubstituted-6-benzylaminopurines has been prepared. The complexes have the following composition: cis-[Pt(Boh)2Cl2] (1), cis-[Pt(Oc)2Cl2] (2), cis-[Pt(Ros)2Cl2] (3), cis-[Pt(i-PrOc)2Cl2] (4), cis-[Pt(BohH+)2Cl2]Cl2 (5), cis-[Pt(OcH+)2Cl2]Cl2 (6), cis-[Pt(RosH+)2Cl2]Cl2 (7) and cis-[Pt(i-PrOcH+)2Cl2]Cl2 (8), where Boh = 2-(3-hydroxypropylamino)-6-benzylamino-9-isopropylpurine, Oc = 2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine, Ros = 2-(R)-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine and i-PrOc = 2-(2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine. Teh complexes have been characterized by elemnetal analyses, conductivity measurements and IR and NMR spectra. The prepared complexeshave been screened for their in vitro cytotoxicity against some cell lines. All complexes are significantly more active than the initial 2,9-disubstituted-6-benzylaminopurine derivates.
Czech name
Syntéza, spektrální studium a cytotoxicita platnatých komplexů s 2,9-disubstituovanými-6-benzylaminopuriny
Czech description
Je popsána syntéza, spektrální studium a cytotoxicita platnatých komplexů s 2,9-disubstituovanými-6-benzylaminopuriny.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA203%2F04%2F1168" target="_blank" >GA203/04/1168: Complexes of selected transition metals with cytokinin derivatives: synthesis, characterization and biological activity</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Inorganic Biochemistry
ISSN
0162-0134
e-ISSN
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Volume of the periodical
99
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
2127-2138
UT code for WoS article
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EID of the result in the Scopus database
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