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Synthesis, spectral study and cytotoxicity of platinum(II) complexes with 2,9-disubstituted-6-benzylaminopurines

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F05%3A00001847" target="_blank" >RIV/61989592:15310/05:00001847 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14310/05:00031136

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Synthesis, spectral study and cytotoxicity of platinum(II) complexes with 2,9-disubstituted-6-benzylaminopurines

  • Original language description

    A series of platinum(II) complexes with 2,9-disubstituted-6-benzylaminopurines has been prepared. The complexes have the following composition: cis-[Pt(Boh)2Cl2] (1), cis-[Pt(Oc)2Cl2] (2), cis-[Pt(Ros)2Cl2] (3), cis-[Pt(i-PrOc)2Cl2] (4), cis-[Pt(BohH+)2Cl2]Cl2 (5), cis-[Pt(OcH+)2Cl2]Cl2 (6), cis-[Pt(RosH+)2Cl2]Cl2 (7) and cis-[Pt(i-PrOcH+)2Cl2]Cl2 (8), where Boh = 2-(3-hydroxypropylamino)-6-benzylamino-9-isopropylpurine, Oc = 2-(2-hydroxyethylamino)-6-benzylamino-9-methylpurine, Ros = 2-(R)-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine and i-PrOc = 2-(2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine. Teh complexes have been characterized by elemnetal analyses, conductivity measurements and IR and NMR spectra. The prepared complexeshave been screened for their in vitro cytotoxicity against some cell lines. All complexes are significantly more active than the initial 2,9-disubstituted-6-benzylaminopurine derivates.

  • Czech name

    Syntéza, spektrální studium a cytotoxicita platnatých komplexů s 2,9-disubstituovanými-6-benzylaminopuriny

  • Czech description

    Je popsána syntéza, spektrální studium a cytotoxicita platnatých komplexů s 2,9-disubstituovanými-6-benzylaminopuriny.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CA - Inorganic chemistry

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA203%2F04%2F1168" target="_blank" >GA203/04/1168: Complexes of selected transition metals with cytokinin derivatives: synthesis, characterization and biological activity</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Inorganic Biochemistry

  • ISSN

    0162-0134

  • e-ISSN

  • Volume of the periodical

    99

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    12

  • Pages from-to

    2127-2138

  • UT code for WoS article

  • EID of the result in the Scopus database