Bio-active Cu(II), Pd(II) and Pt(II) complexes of 6-benzylaminopurine derivatives

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F01%3A00004388" target="_blank" >RIV/00216224:14310/01:00004388 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Bio-active Cu(II), Pd(II) and Pt(II) complexes of 6-benzylaminopurine derivatives
Original language description
In the course of our research on transition metal complexes with anticancer activity,1 a series of mononuclear Cu(II), Pd(II) and Pt(II) complexes with selected 6-benzylaminopurine derivatives, namely 6-(2-hydroxybenzylamino)purine 2OHBAP, 6-(3-fluorobenzylamino)purine 3FBAP, 2-(3-hydroxypropylamino)-6-benzylamino-9-isopropylpurine BOH and 2-(2-hydroxyethylamino)-6-benzylamino-9-metylpurine OLO, has been synthesized and characterized by elemental analysis, electronic, infrared and mass (FAB+, ESI+) spectral data, magnetic susceptibility and molar conductivity data. On the basis of data resulting mainly from a single crystal X-ray analysis, a composition of the prepared complexes is following: [CuCl3(2OHBAP+)2]Cl.2H2O, [CuCl3(3FBAP+)2]Cl.H2O, [PdCl3(BOH+)].H2O, [PdCl3(OLO+)].H2O, [PtCl3(BOH+)].H2O, [PtCl3(OLO+)].H2O. Cytotoxic activity of the complexes as well as the starting compounds was determined by a calcein AM assay on various human tumor cell lines.
Czech name
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Czech description
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Project
<a href="/en/project/GA203%2F00%2F0152" target="_blank" >GA203/00/0152: Synthesis, study and biology activity of coordination compounds of selected transition metals with purine derivatives</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2001
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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