Electrochemical oxidation of fesoterodine and identification of its oxidation products using liquid chromatography and mass spectrometry

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F15%3A33156324" target="_blank" >RIV/61989592:15310/15:33156324 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/15:00091052
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0013468615002364" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0013468615002364</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.electacta.2015.01.190" target="_blank" >10.1016/j.electacta.2015.01.190</a>

Result language
angličtina
Original language name
Electrochemical oxidation of fesoterodine and identification of its oxidation products using liquid chromatography and mass spectrometry
Original language description
The electrochemical behavior of fesoterodine (FES), an antimuscarinic drug used for the treatment of urge incontinence and overactive bladder, was investigated using linear sweep and cyclic voltammetry at a stationary and rotating disc glassy carbon electrodes. A single two-electron anodic signal of FES was observed in neutral buffered aqueous methanolic solutions. Kinetics of alkaline hydrolysis of FES to its active metabolite 5-hydroxymethyl tolterodine was investigated by time dependent linear sweepvoltammetry. Controlled potential electrolysis of FES solutions was performed at platinum gauze electrode in aqueous-methanolic media. Electrolyzed solutions were analyzed using ultra performance liquid chromatography with electrospray ionization quadrupole time-of-flight mass spectrometry. Two main products of electrochemical oxidation of fesoterodine were identified as 5-formyl fesoterodine (isobutyric acid 2-(3-diisopropylamino-1-phenyl-propyl)-4-formyl-phenyl ester) and N-desisopropy
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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